Human clock12/2/2023 ![]() ![]() Herein, patients with COPD showed lower Bmal1 and Clock expression in the plasma. The regulation of ciracadian clock expression and cell senescence by cigarette smoke extract (CSE) was studied in vitro, and small interfering RNA (siRNA) and overexpression of Bmal1 or Clock were employed to investigate the role of circadian clock on cell senescence. Bmal1 and Clock levels were assessed in the plasma samples of non-smokers, smokers, and patients with COPD. ![]() The aim of this study is to investigate the role of the circadian clock protein BMAL1 and CLOCK in cellular senescence in order to understand the cellular mechanisms of accelerated aging of COPD. Although the circadian molecular clock regulates cellular senescence, there is no information available regarding the impact of COPD. Circadian clock is believed to play important roles in COPD. COPD is associated with accelerated lung aging. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.Ĭhronic obstructive pulmonary disease (COPD) is a progressive respiratory disease. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. ![]() The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. ![]()
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